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If THC absorption is high enough to produce psychoactive effects, the risk of a detectable urine concentration while still unlikely to reach the 50 ng/mL DOT cutoff increases meaningfully compared to outdoor or ventilated exposure

FUNDING This work was supported by the National Institutes of Health (NIH) and the FDA Center for Tobacco Products (Award number: U01CA278695, to C.D

Strictly speaking, the tests often look for cotinine and not nicotine because cotinine is more stable and lasts longer in the body, and is only present after nicotine is broken down (4)

12 Severe cocaine-induced psychosis may be marked by hostility, aggressiveness, and extreme paranoia